生命科学学院

Huiying Li, Yuhao Qiu, Bowen Song, Xinyi Quan, Dan Zhang, Xinru Li, Jingyun Yang, Xiaohong Liu, Zhiyang Zeng, Ji Jing, Shuming Yin, Qi Dai, Liren Wang, Honghui Han, Haifeng Ye, Zhenliang Sun, Yiyun Cheng, Xueli Zhang, Bing Du*, Mingyao Liu*, Dali Li*. Engineering a photoactivatable A-to-I RNA base editor for gene therapy in vivo. Nature Biotechnology. 2025 March 31. Doi:10.1038/s41587-025-02610-2. IF: 33.1

Binghe Tan, Chuntian Tu, Hao Xiong, Yongqian Xu, Xiujuan Shi, Xiaolin Zhang, Ruijie Yang, Na Zhang, Boxu Lin, Mingyao Liu, Juliang Qin*, Bing Du*. GITRL enhances cytotoxicity and persistence of CAR-T cells in cancer therapy. Molecular Therapy. 2025 Jan 25:S1525-0016(25)00040-1. doi: 10.1016/j.ymthe.2025.01.036. IF: 12.4

Xiaobing Wang, Xin Wu, Binghe Tan, Liang Zhu, Yi Zhang, Li Lin, Yi Xiao, An Sun, Xinyi Wan, Shiyuan Liu, Yanfang Liu, Na Ta, Hang Zhang, Jialin Song, Ting Li, Ling Zhou, Jian Yin, Lingying Ye, Hongjuan Lu, Jinwei Hong, Hui Cheng, Ping Wang, Weiqing Li, Jianfeng Chen, Jin Zhang, Jing Luo, Miaozhen Huang, Lehang Guo, Xiaoming Pan, Yi Jin, Wenjing Ye, Lie Dai, Jian Zhu, Lingyun Sun, Biao Zheng, Dali Li, Yanran He, Mingyao Liu*, Huaxiang Wu*, Bing Du*, Huji Xu*, Allogeneic CD19-targeted CAR-T therapy in patients with severe myositis and systemic sclerosis, Cell, 2024 Jul 9:S0092-8674(24)00701-3. doi: 10.1016/j.cell.2024.06.027.IF: 45.5

Zeda Zhao, Juliang Qin, Ying Qian, Chenshen Huang, Xiaohong Liu, Ning Wang, Liqin Li, Yuqing Chao, Binghe Tan, Na Zhang, Min Qian, Dali Li, Mingyao Liu, Bing Du*, FFAR2 expressing myeloid-derived suppressor cells drive cancer immunoevasion. Journal of Hematology & Oncology, 2024 Feb 24;17(1):9. doi: 10.1186/s13045-024-01529-6. IF: 29.5

X. Chen, B. Tan, H. Xing, X. Zhao, Y. Ping, Z. Zhang, J. Huang, X. Shi, N. Zhang, B. Lin, W. Cao, X. Li, X. Zhang, L. Li, Z. Jiang, M. Zhang, W. Li, M. Liu, Bing Du*, Yi Zhang*, Allogeneic CAR-T cells with of HLA-A/B and TRAC disruption exhibit promising antitumor capacity against B cell malignancies. Cancer Immunology, Immunotherapy, 2024;73(1):13. DOI: 10.1007/s00262-023-03586-1. IF: 5.8

Na Zhang, Xiaohong Liu, Juliang Qin, Yue Sun, Hao Xiong, Boxu Lin, Kexin Liu, Binghe Tan, Chenglin Zhang, Chenshen Huang, Shancheng Ren*, Mingyao Liu*, Bing Du*. LIGHT/TNFSF14 promotes CAR-T cell trafficking and cytotoxicity through reversing immunosuppressive tumor microenvironment. Molecular Therapy, Published on line July 04, 2023, doi:10.1016/j.ymthe.2023.06.015. IF: 12.4

Jiqin Zhang*, Yongxian Hu, Jiaxuan Yang, Wei Li, Mingming Zhang, Qingcan Wang, Linjie Zhang, Guoqing Wei, Yue Tian, Kui Zhao, Ang Chen, Binghe Tan, Jiazhen Cui, Deqi Li, Yi Li, Yalei Qi, Dongrui Wang, Yuxuan Wu, Dali Li*, Bing Du*, Mingyao Liu* & He Huang*. Non-viral, specifically targeted CAR-T cells achieve high safety and efficacy in B-NHL. Nature. Published: 31 August 2022, doi: 10.1038/s41586-022-05140-y. IF: 69.504

Chenshen Huang, Ning Wang, Na Zhang, Zhizhong Chen, Zhizhan Ni, Xiaohong Liu, Hao Xiong, Huahao Xie, Boxu Lin, Bujun Ge*, Qi Huang* and Bing Du*. Multi-omics analysis for potential inflammation-related genes involved in tumour immune evasion via extended application of epigenetic data. Open Biology. Published on line 10 August 2022, doi: 10.1098/rsob.210375. IF: 7.124

Su Zhang, Fangfei Yu, Anran Che, Binghe Tan, Chenshen Huang, Yuxue Chen, Xiaohong Liu, Qi Huang, Wenying Zhang, Chengbin Ma, Min Qian, Mingyao Liu*, Juliang Qin*, Bing Du*,Neuroendocrine Regulation of Stress-Induced T Cell Dysfunction during Lung Cancer Immunosurveillance via the Kisspeptin/GPR54 Signaling Pathway. Advanced Science (Weinh). 2022 May;9(13):e2104132. doi: 10.1002/advs.202104132. IF: 17.521

Chenshen Huang, Na Zhang, Hao Xiong, Ning Wang, Zhizhong Chen, Zhizhan Ni, Xiaohong Liu, Boxu Lin, Bujun Ge, Bing Du*, Qi Huang*, Multi-Omics Analysis for Transcriptional Regulation of Immune-Related Targets Using Epigenetic Data: A New Research Direction. Frontiers in Immunology, 03 January 2022, doi:10.3389/fimmu.2021.741634 IF: 8.786

Xiaoyu Zhang, Wenxiang Zhao, Yihan Zhao, Zeda Zhao, Zhangsheng Lv, Zhen Zhang, Hua Ren, Qin Wang, Mingyao Liu, Min Qian, Bing Du*, Juliang Qin*, Inflammatory macrophages exacerbate neutrophil-driven joint damage through ADP/P2Y1 signaling in rheumatoid arthritis. Science China-Life Sciences, 2022 May;65(5):953-968. doi: 10.1007/s11427-020-1957-8 IF: 10.372

[10] Yan Lou , Wenxiang Zhao , HaitaoWei, Min Chu, Ruihua Chao, Hangping Yao, Junwei Su, Yanan Li, Xiulan Li, Yu Cao, Yanyan Feng, PingWang, Yongyang Xia, Yushuan Shang, Fengping Li, Pingju Ge, Xinglin Zhang, Wenjing Gao, Gaojie Song, Bing Du*, Tingbo Liang*, Yunqing Qiu*, Mingyao Liu*, Cross-neutralization of RBD mutant strains of SARS-CoV-2 by convalescent patient derived antibodies Biotechnology Journal, 2021,April 21, doi: 10.1002/biot.202100207 IF: 5.726

Juliang Qin, Xiaoyu Zhang, Binghe Tan, Su Zhang, Chengcong Yin, Qi Xue, Zhen Zhang, Hua Ren, Jinlian Chen, Mingyao Liu, Min Qian and Bing Du*. Blocking P2X7-Mediated Macrophage Polarization Overcomes Treatment Resistance in Lung Cancer. Cancer Immunology Research, 2020 Nov;8(11):1426-1439. doi: 10.1158/2326-6066.CIR-20-0123 IF: 12.020

Chengfei Zhang#, Juliang Qin#, Su Zhang, Na Zhang, Binhe Tan, Stefan Siwko, Ying Zhang, Qin Wang, Jinlian Chen, Min Qian, Mingyao Liu*, Bing Du*. ADP/P2Y1 aggravates inflammatory bowel disease through ERK5 mediated NLRP3 inflammasome activation. Mucosal Immunology, 2020 Nov;13(6):931-945. doi: 10.1038/s41385-020-0307-5 IF: 8.701

Qin Juliang#, Zhang Zhen#, Fu Zhixiang, Ren Hua, Liu Mingyao, Qian Min, Du Bing*. The UDP/P2y6 axis promotes lung metastasis of melanoma by remodeling the premetastatic niche. Cellular & Molecular Immunology, 2020 Dec;17(12):1269-1271. doi: 10.1038/s41423-020-0392-0. IF: 22.096

Wu Nannan#, Nguyen XN#, Wang Li#, Appourchaux R, Zhang Chengfei, Panthu B, Gruffat H, Journo C, Alais S, Qin Juliang, Zhang Na, Tartour K, Catez F, Mahieux R, Ohlmann T, Liu Mingyao, Du Bing*, Cimarelli A*. 2019. The interferon stimulated gene 20 protein (ISG20) is an innate defense antiviral factor that discriminates self versus non-self translation. PLoS Pathogens. 2019 Oct 10;15(10):e1008093. doi: 10.1371/journal.ppat.1008093. IF: 7.464

Pei Haixiang#, Qin Juliang#, Wang Fengmian, Tan Binghe, Zhao Zeda, Peng Yangrui, Yu Fangfei, Li Ennian, Liu Mingyao, Zhang Rong, Liu Bo*, Du Bing*, Chen Yihua*. 2019. Discovery of potent ureido tetrahydrocarbazole derivatives for cancer treatments through targeting tumor-associated macrophages. European Journal of Medicinal Chemistry. 2019 Sep 28;183:111741. doi: 10.1016/j.ejmech.2019.111741. IF: 6.514

Wang Ning, Huang Hongjun, Xiong Qingqing, Chen Naiyang, Xi Nanxi, Wu Peilun, Liu Mingyao, Qian Min, Wang Qin, Du Bing*. 2019. GNAQ Negatively Regulates Antiviral Innate Immune Responses in a Calcineurin-Dependent Manner. Journal of Immunology, 2019, Jul 19. pii: ji1900427. doi: 10.4049/jimmunol.1900427. IF: 5.426

Zhang Chengfei, Yan Yan, He Hongwang, Wang Li, Zhang Na, Huang Hongjun, Wu Nannan, Ren Hua, Qian Min, Liu Mingyao, Du Bing*. 2019. IFN-stimulated P2Y13 protects mice from viral infection by suppressing the cAMP/EPAC1 signaling pathway. Journal of Molecular Cell Biology, 2019, 11(5): 395-407, DOI: 10.1093/jmcb/mjy045. IF: 8.185

Xiong Qingqing, Huang Hongjun, Wang Ning, Chen Ruoyu, Chen Naiyang, Han Honghui, Wang Qin, Stefan Siwko, Liu Mingyao, Qian Min, Du Bing*. 2018. Metabolite-Sensing G Protein Coupled Receptor TGR5 Protects Host from Viral Infection through Amplifying Type I Interferon Responses. Frontiers in Immunology, September 14, 2018, doi:10.3389/fimmu.2018.02289. IF: 8.786

Huang hongjun, Xiong Qingqing, Wang Ning, Chen Ruoyu, Ren Hua, Stefan Siwko, Han Honghui, Liu Mingyao, *Qian Min, Du Bing*. 2018. Kisspeptin/GPR54 Signaling Restricts Antiviral Innate Immune Response through Regulating Calcineurin Phosphatase Activity. Science Advances, 2018 Aug 8;4(8):eaas9784. doi: 10.1126/sciadv.aas9784. IF: 14.957

Tan Binghe, Shi Xiujuan, Zhang Jie, Qin Juliang, Zhang Na, Ren Hua, Qian Min, Stefan Siwko, Kendra Carmon, Liu Qingyun, Han Honghui, Du Bing*, Liu Mingyao*. 2018. Inhibition of Rspo-Lgr4 facilitates checkpoint blockade therapy by switching macrophage polarization. Cancer Research, September 1 2018 78 (17) 4929-4942; DOI:10.1158/0008-5472.CAN-18-0152. Cover story and Issue Highlights. IF: 13.312

Zhang Xiaoyu, Qin Juliang, Zou Junyan, Lv Zhangsheng, Tan Binhe, Shi Jueping, Zhao Yihan, Ren Hua, Liu Mingyao, Qian Min, Du Bing*. 2018. Extracellular ADP facilitates monocyte recruitment in bacterial infection via ERK signaling. Cellular & Molecular Immunology. 2018 Jan;15(1):58-73. doi: 10.1038/cmi.2016.56. IF: 22.096

Zhang Na, Huang Hongjun, Tan Binghe, Wei Yinglei, Xiong Qingqing, Yan Yan, Hou Lili, Wu Nannan, Siwko Stefan, Andrea Cimarelli, Xu Jianrong, Han Honghui, Qian Min, Liu Mingyao*, Du Bing*. 2017. Leucine-rich repeat-containing G protein-coupled receptor 4 facilitates vesicular stomatitis virus infection by binding vesicular stomatitis virus glycoprotein. Journal of Biological Chemistry, 2017 Aug 23. pii: jbc.M117.802090. doi: 10.1074/jbc.M117.802090. IF: 5.486

Zhang Chengfei, He Hongwang, Wang Li, Zhang Na, Huang Hongjun, Xiong Qingqing, Yan Yan, Wu Nannan, Ren Hua, Han Honghui, Liu Mingyao, Qian Min, Du Bing*. 2017. Virus-Triggered ATP Release Limits Viral Replication through Facilitating IFN-β Production in a P2X7-Dependent Manner. Journal of Immunology. 2017 August 15;199 (4) 1372-1381; DOI: 10.4049/jimmunol.1700187. IF: 5.422

Huang Hongjun, Zhang Na, Xiong Qingqing, Chen Ruoyu, Zhang Chengfei, Wang Ning, Wang Li, Ren Hua, Liu Mingyao, *Qian Min, Du Bing*. 2017.Elimination of GPR146-mediated antiviral function through IRF3/HES1-signaling pathway. Immunology. 2017 Sep;152(1):102-114. doi: 10.1111/imm.12752. IF: 7.215

Qin Juliang, Zhang Xiaoyu, Wang Ziqiang, Li Jinju, Zhang Zhen, Gao Liangcai, Ren Hua, *Qian Min, Du Bing*. 2017. Presenilin 2 deficiency facilitates Aβ-induced neuroinflammation and injury by upregulating P2X7 expression. SCIENCE CHINA Life Sciences. 2017 Feb;60(2):189-201. doi: 10.1007/s11427-016-0347-4. IF: 10.372

Ma Xiaobin, Pan Xinhua, Wei Yinglei, Tan Binhe, Yang Linli, Ren Hua, Qian Min, Du Bing*. 2016. Chemotherapy-induced uridine diphosphate release promotes breast cancer metastasis through P2Y6 activation. Oncotarget. 2016 May 17;7(20):29036-50. doi: 10.18632/oncotarget.8664. IF: 5.168

Shi, G., X. He, *Y. Shang, L. Xiang, C. Yang, G. Han, and Du Bing*. 2016. Synthesis of 3′,4′‐Diaryl‐4′H‐spiro[indoline‐3,5′‐[1′,2′,4′]oxadiazol]‐2‐ones via DMAP‐catalyzed Domino Reactions and Their Antibacterial Activity. Chinese Journal of Chemistry 34: 901-909. IF: 1.852

Qin Juliang, Zhang Guangxu, Zhang Xiaoyu, Tan Binghe, Lv Zhangsheng, Liu Mingyao, Ren Hua, Qian Min, Du Bing*. 2016. TLR-Activated Gap Junction Channels Protect Mice against Bacterial Infection through Extracellular UDP Release. Journal of Immunology. 15;196(4):1790-8. IF: 5.422

Zhang Xiaoyu, Qin Juliang, Zhao Yihan, Shi Jueping, Lan Rong, Gan Yunqiu, Ren Hua, Zhu Bing, Qian Min, Du Bing*. 2016. Long-term ketogenic diet contributes to glycemic control but promotes lipid accumulation and hepatic steatosis in type 2 diabetic mice. Nutrition Research. 36(4):349-58. IF: 3.315

Li Jinju, Zhang Guangxu, Cheng Dalong, Ren Hua, Qian Min, Du Bing*. 2015. Molecular characterization of RIG-I, STAT-1 and IFN-beta in the horseshoe bat. Gene. 561(1):115-23. IF: 2.638

Li Ruimei, Tan Binhe, Yan Yan, Ma Xiaobing, Zhang Na, Zhang Zhi, Liu Mingyao, Qian Min and Du Bing*, 2014. Extracellular UDP and P2Y6 function as a danger signal to protect mice from vesicular stomatitis virus infection through an increase in IFN-beta production. Journal of Immunology. 193, 4515-26. IF: 5.422

Ren Hua, Teng Yunfei, Tan Binhe, Zhang Xiaoyu, Jiang Wei, Liu Mingyao, Jiang Wenzheng, Du Bing*and *Qian, Min, 2014. Toll-like receptor-triggered calcium mobilization protects mice against bacterial infection through extracellular ATP release. Infection and Immunity. 82, 5076-85. IF: 3.441

Du Bing & *Liu Mingyao, 2014. Structure of the human P2Y(1)(2) receptor in complex with an antithrombotic drug. Science China. Life sciences. 57, 645-646. IF: 6.038

Du Bing, Luo Weijia, Li Ruimei, Tan Binghe, Han Honghui, Lu Xiaoling, Li Dali, Qian Min, Zhang Dekai, Zhao Yongxiang, * Liu Mingyao,2013. Lgr4/Gpr48 Negatively Regulates TLR2/4-associated Pattern Recognition and Innate Immunity by Targeting CD14 Expression, Journal of Biological Chemistry. 2013, 288(21), pp 15131-15141. IF: 5.157

Zhao Qufei, Qian Yu, Li Ruimei, Tan Binghe, Han Honghui, Liu Mingyao, * Qian Min, Du Bing*,2012. Norcantharidin Facilitates LPS-Mediated Immune Responses by Up-Regulation of AKT/NF-kappaB Signaling in Macrophages, Plos One, 7(9), p e44956. IF: 3.24

Wang Ziqiang, Jiang Wei, Zhang Zhi, Qian Min, Du Bing*,2012. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kappaB pathway in RAW 264.7 cells,Journal of Ethnopharmacol. 144(1), pp 145-150. IF: 4.36

Pan Xinhua, Han Honghui, Wang Lei, Yang Linli, Li Ruimei, Li Zhenxi, Liu Junchen, Zhao Qufei, Qian Min, * Liu Mingyao, Du Bing*,2011. Nitidine Chloride inhibits breast cancer cells migration and invasion by suppressing c-Src/FAK associated signaling pathway,Cancer Letters, 313(2), pp 181-191. IF: 8.679

Zhang Zhi、Wang Ziqiang、Ren Hua、Yue Miaomiao、Huang Kan、Gu Hongjie、Liu Mingyao、Du Bing*、Qian Min*,2011. P2Y(6) Agonist Uridine 5 '-Diphosphate Promotes Host Defense against Bacterial Infection via Monocyte Chemoattractant Protein-1-Mediated Monocytes/Macrophages Recruitment,Journal of Immunology, 186(9), pp 5376-5387. IF: 4.539

Han H, Du Bing, Pan X, Liu J, Zhao Q, Lian X, et al. CADPE inhibits PMA-stimulated gastric carcinoma cell invasion and matrix metalloproteinase-9 expression by FAK/MEK/ERK-mediated AP-1 activation. Molecular Cancer Research,2010;8:1477-88. IF: 5.852

Du Bing, Han H, Wang Z, Kuang L, Wang L, Yu L, et al. Targeted drug delivery to hepatocarcinoma in vivo by phage-displayed specific binding peptide. Molecular Cancer Research, 2010;8:135-44. IF: 5.852

Du Bing, M. Qian, Z. Zhou, P. Wang, L. Wang, X. Zhang, M. Wu, P. Zhang, and B. Mei. 2006. In vitro panning of a targeting peptide to hepatocarcinoma from a phage display peptide library. Biochemical and biophysical research communications 342: 956-962. IF: 3.575